SCR-1481B1 | Gasdermin D inhibitor 

CAS:1174161-86-4

Catalog Number:10-3971

SCR-1481B1 (1174161-86-4) is an inhibitor of HGFR (Met) and VEGFR kinases.1 SCR-1481B1 potently suppresses

 gasdermin D-mediated pyroptosis via targeting of the oligomerization interface I.2 Active in vivo in a mouse model 

of sepsis. SCR-1481B1 acts synergistically with another gasdermin D inhibitor, Cefcapene pivoxil (Cat #10-3972), 

and a PD-L1 antibody to significantly enhance the antitumor activity of anti-PD-L1 therapy.

CAS:1174161-86-4

Catalog Number:10-3971

Activity:Gasdermin D inhibitor

Chemical Names:[3-[[4-(2-Amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]carbamoyl]-5-(4-fluorophenyl)-4-oxopyridin

-1-yl]methyl dihydrogen phosphate;di 2-amino-2-(hydroxymethyl)propane-1,3-diol salt

Alternate Name:Metatinib tromethamine

Molecular Weight:821.13

Molecular Formula:C24H18ClF2N4O7P·2C4H11NO3

Solubility:Soluble in DMSO (>25 mg/ml)

Physical Properties:White solid

Purity:>98% HPLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:

Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:RT

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References/CItations:

Borzilleri and Cai (2012), 4-Pyridone compounds and their use for cancer; US8258118B2

Hu et al. (2024), Identification of two repurposed drugs targeting GSDMD oligomerization interface I to block pyroptosis; Cell Chem. Biol. 31 P2024