Canine_PDL1 293T Cell Line

SKU: CEL100114

Target:Canine_PDL1

Description:Monoclonal Cell Line Derived from 293T Cells, Engineered for Stable Expression of canine PDL1 Using Lentiviral Technology

Host Cells:293T

Uniprot ID:NP_001278901.1

Applications:FACS Data

Growth media:DMEM+10% FBS+1% P.S+Gln+2 ug/mL Puromycin

Package:5E6 Cells/mL

Host Species:canine

Suggested Control:SKU: PME-D100009

Warranty and Disclaimer

1. Please inspect cells upon receipt and report any issues promptly. 

2. We offer one-time replacements for issues reported within a week of receipt. 

3. User-induced issues are not eligible for free replacements. 

4. We do not accept liability for damages resulting from cell use, storage, or loss. 

5. Feedback received more than one month after receipt will not be processed.

Storage & Shipping:Cells are shipped using dry ice and require liquid nitrogen storage for long term preservation.

Synonyms:B7-H, B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1, hPD-L1

Background:This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Usage:For research use only.

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