Elzovantinib 

Elzovantinib, also known as TPX-0022 and CSF1R-IN-2, is an orally bioavailable CSF1R inhibitor with a novel three-dimensional macrocyclic structure that inhibits the MET, CSF1R (colony stimulating factor 1 receptor) and SRC kinases. Targeting CSF1R leads to the modulation of tumor-associated macrophages (TAMs), a type of immune cell that suppresses the T-cell mediated anti-tumor immune response. Inhibition of CSF1R with TPX-0022 is a promising therapeutic strategy as a single agent or in combination with standard of care chemotherapy and immunotherapy in various solid tumors.

MedKoo Cat#: 408118

Name: Elzovantinib

CAS#: 2271119-26-5

Chemical Formula: C20H20FN7O2

Exact Mass: 409.1663

Molecular Weight: 409.43

Elemental Analysis: C, 58.67; H, 4.92; F, 4.64; N, 23.95; O, 7.82

Related CAS #:No Data

Synonym:TPX-0022; TPX 0022; TPX0022; CSF1R-IN-2; Elzovantinib; CSF1R Inhibitor 2; NSC820832; NSC 820832; NSC-820832;

IUPAC/Chemical Name:(S,13E,14E)-12-amino-2-ethyl-45-fluoro-6-methyl-9-oxo-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(1,2)-benzenacyclononaphane-46-carbonitrile

InChi Key:UUDPUQDMSHQSKH-NSHDSACASA-N

InChi Code:InChI=1S/C20H20FN7O2/c1-3-27-10-13-12(8-22)14(21)4-5-15(13)30-11(2)9-24-20(29)17-18(23)26-28-7-6-16(27)25-19(17)28/h4-7,11H,3,9-10H2,1-2H3,(H2,23,26)(H,24,29)/t11-/m0/s1

SMILES Code:N#CC1=C2CN(CC)C(C=C3)=NC(N3N=C4N)=C4C(NC[C@H](C)OC2=CC=C1F)=O

Appearance:Solid powder

Purity:>98% (or refer to the Certificate of Analysis)

Shipping Condition:Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:Soluble in DMSO

Shelf Life:>3 years if stored properly

Drug Formulation:This drug may be formulated in DMSO

Stock Solution Storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 409.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

[1]. WO 2019023417 A1.

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