Glycodeoxycholic Acid-d4 MaxSpec® Standard

Glycodeoxycholic acid-d4 (GDCA-d4) is intended for use as an internal standard for the quantification of glycodeoxycholic acid by GC- or LC-MS. GDCA is a glycine-conjugated form of the secondary bile acid deoxycholic acid.<sup class="referenceList">[1]</sup> It induces a reversible, concentration-dependent reduction in myogenic tone in rats and decreases expression of the gene encoding the cytochrome P450 (CYP) isoform 7A1 (CYP7A1) in rabbits.<sup class="referenceList">[2],[3]</sup> Serum levels of GDCA are elevated in non-surviving patients with acetaminophen-induced acute liver failure (AALF) compared with survivors.<sup class="referenceList">[4]</sup> GDCA levels are also increased in the plasma of patients with asthma.<sup class="referenceList">[5]</sup> Glycodeoxycholic acid-d4 MaxSpec^® standard is a quantitative grade standard of glycodeoxycholic acid-d4 that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This glycodeoxycholic acid-d4 MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

Item No.:TX01FP8H

CAS No.:1069132-37-1

Molecular Formula:C26H39D4NO5

Molecular Weight:453.6480

Technical Information

Item No.:TX01FP8H

Product Name:Glycodeoxycholic Acid-d4 MaxSpec® Standard

Description:

Synonyms:GDCA-d4; Glycodeoxycholic Acid-d4 MaxSpec® Standard; Glycodeoxycholic acid-d4

CAS Number:1069132-37-1

MDL:MFCD00784362

Molecular Formula:C26H39D4NO5

Molecular Weight:453.6480

SMILES:C[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C

Shipping Condition:Room temperature in continental US; may vary elsewhere.

References & Citations:

[1]. 1.Comhair, S.A.A., McDunn, J., Bennett, C., et al. Metabolomic endotype of asthma J. Immunol. 195(2),643-650 (2015).

[2]. Khurana, S., Raina, H., Pappas, V., et al. Effects of deoxycholylglycine, a conjugated secondary bile acid, on myogenic tone and agonist-induced contraction in rat resistance arteries PLoS One 7(2),e32006 (2012).

[3]. Shang, Q., Guo, G.L., Honda, A., et al. Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits Am. J. Physiol. Gastrointest. Liver Physiol. 307(4),G479-G486 (2014).

[4]. Woolbright, B.L., McGill, M.R., Staggs, V.S., et al. Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients Toxicol. Sci. 142(2),436-444 (2014).

[5]. Lefebvre, P., Cariou, B., Lien, F., et al. Role of bile acids and bile acid receptors in metabolic regulation Physiol. Rev. 89(1),147-191 (2009).

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