Cyclophosphamide 

Catalog NO.: 50-18-0 

CAS NO.: 50-18-0 

Brand: BOC Sciences

CategoryInhibitor:Tag/TargetsDNA Alkylator/Crosslinker Others (Nonspecific immune stimulation)

Molecular FormulaC7H15Cl2N2O2P:Molecular Weight261.09

Product Description:Low-dose preferentially deplets Treg cells; An alkylating agent of the nitrogen mustard type with antineoplastic and immunosuppressive activities; Phase I-II

Related CAS:6055-19-2 (hydrate) 50-18-0 (anhydrous)

Appearance:Fine White lyophilised solid

Synonyms:Cytoxan; Clafen; Neosar; CTX; 2-Bis(2-chloroethyl)aminotetrahydro-2H-1,3,2-oxazophosphorine-2-oxide; N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

Solubility:In water, 1-5 g/100 mL at 23 °C; slightly soluble in benzene, carbon tetrachloride; very slightly soluble in ether and acetone.

Storage:Stored at room temp or within 6 days if stored under refrigeration. When constituted with sterile water for injection or paraben-preserved bacteriostatic water for injection to a concn of 21 mg/ml, <1.5% cyclophosphamide decomposition will occur within 8

Quality: StandardIn-house

PROPERTIES

Quantity:Grams-Kilos

Boiling Point:336

Melting Point:41-45°C

Density:1.3±0.1 g/cm3

InChI Key:CMSMOCZEIVJLDB-UHFFFAOYSA-N

InChI:InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)

SMILES:C1CNP(=O)(OC1)N(CCCl)CCCl

REFERENCES

1.Control of nausea with palonosetron versus granisetron, both combined with dexamethasone, in patients receiving cisplatin- or anthracycline plus cyclophosphamide-based regimens.

Kubota K1, Saito M2, Aogi K3, Sekine I4, Yoshizawa H5, Yanagita Y6, Sakai H7, Inoue K8, Kitagawa C9, Ogura T10. Support Care Cancer. 2016 Apr 29. [Epub ahead of print]

PURPOSE: In a comparative phase 3 study involving 1114 Japanese patients receiving highly emetogenic chemotherapy (HEC), palonosetron (PALO) was found to be superior to granisetron (GRA) for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) in the delayed phase. This post hoc analysis of the phase 3 study evaluated the efficacy of PALO for the control of nausea.

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