CAT335

(HB8146)

Name:CAT335

Purity:>98%

Description:K2P2.1 (TREK-1) modulator. Used with ML336 as part of the CATKLAMP chemogenetic strategy. Selectively and irreversibly activates TREK-1CG* but not wild-type K2P2.1 (TREK-1)

Biological description:K2P2.1 (TREK-1) modulator. Recently used with ML 336 as part of the CATKLAMP chemogenetic strategy which uses the pair of compounds to rapidly and irreversiblly activate engineered TREK subfamily members to allow further probing of K2P function and act as a switch to silence neuronal firing. Selectively and covalently activates engineered versions of different K2P TREK subfamily members when used with ML 336, e.g. K2P2.1 (TREK-1), K2P10.1 (TREK-2), K2P4.1(TRAAK).

Storage instructions:Room temperature

Solubility overview:Soluble in DMSO (100 mM)

Important:This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Purity:>98%

Chemical name:N-[(2,4-dichlorophenyl)methyl]-4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzamide

Molecular Weight:375.21

Molecular Formula:C18H12Cl2N2O3

SMILES:Clc1ccc(CNC(=O)c2ccc(cc2)N2C(=O)C=CC2=O)c(Cl)c1

Source:Synthetic

InChi:InChI=1S/C18H12Cl2N2O3/c19-13-4-1-12(15(20)9-13)10-21-18(25)11-2-5-14(6-3-11)22-16(23)7-8-17(22)24/h1-9H,10H2,(H,21,25)

InChiKey:KSVANLMIIBANJX-UHFFFAOYSA-N

Licensing details:Sold under license from the Regents of the University of California

This product is for in vitro research use only. It is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for commercial purposes, contact The Regents of the University of California. This product or the use of this product is covered by U.S. Patent owned by The Regents of the University of California.

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