Tumor Cell Lines -QGP-1

Human pancreatic islet cell carcinoma cell line with carcinoembryonic antigen (CEA)-positive. This cell line secretes somatostatin, but not RI and RI B, suggesting that this cell line originates from islet D-cells.

Product Code:QGP 1; QGP1

Species:Human

Cat.No:ABC-TC0918

Product Category:Tumor Cell Lines

Size/Quantity:1 vial

Cell Type:Epithelial-like

Shipping Info:Dry Ice

Growth Conditions:37 ℃, 5% CO2

Source Organ:Pancreas

Biosafety Level:1

Storage:Liquid Nitrogen

Product Type:Human Pancreas Cancer Cell Lines

QGP-1 is a human pancreatic neuroendocrine tumor cell line derived from the pancreas of a male patient with a carcinoid tumor. These epithelial-like cells are polygonal or rounded and grow adherently in standard culture conditions (37°C, 5% CO₂). The cell line expresses neuroendocrine markers such as carcinoembryonic antigen (CEA) and synaptophysin, and shows elevated expression of transcription factors related to neuroendocrine differentiation, immature pancreatic β/δ-cell genes. The cell line exhibits genomic instability, with a portion of the cells showing a tetraploid karyotype. This cell line also exhibits the expression of somatostatin receptors (SSTR2 and SSTR5), making it an important in vitro model for studying pancreatic neuroendocrine tumors (pNETs).

CITATION

Si, Y., Kim, S., Guenter, R., Ou, J., Lu, Y., Chen, K., Zhang, J., Whitt, J., Carter, A.M., Bibb, J.A. and Jaskula-Sztul, R., 2019. Anti-SSTR2 Antibody-Drug Conjugate for Neuroendocrine Cancer Therapy. bioRxiv, p.688184.

Si, Y., Guan, J., Xu, Y., Chen, K., Kim, S., Zhou, L., Jaskula-Sztul, R. and Liu, X.M., 2020. Dual-Targeted Extracellular Vesicles to Facilitate Combined Therapies for Neuroendocrine Cancer Treatment. Pharmaceutics, 12(11), p.1079.

Herring, B., Jang, S., Whitt, J., Goliwas, K., Aburjania, Z., Dudeja, V., Ren, B., Berry, J., Bibb, J., Frost, A. and Chen, H., 2021. Ex Vivo Modeling of Human Neuroendocrine Tumors in Tissue Surrogates. Frontiers in endocrinology, 12.

APPLICATION

QGP-1 cell line can serve as an in vitro cell model for neuroendocrine tumor (NET) drug development. In addition, the QGP-1 cell line is also an excellent model for studying human enterochromaffin (EC) cells. Because it highly expresses EC cell marker genes and transient receptor potential ankyrin 1 (TRPA1), it can be used to further explore the function and regulatory mechanism of TRPA1 in EC cells.

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