anti-TG antibody :: Mouse Thyroglobulin Monoclonal Antibody

Product Name:Thyroglobulin (TG), Monoclonal Antibody 

Full Product Name:Thyroglobulin (T3/T4) Monoclonal Antibody

Product Synonym Names:Anti-Thyroglobulin; Thyroglobulin

Product Gene Name:anti-TG antibody[Similar Products]

Research Use Only:For Research Use Only. Not for use in diagnostic procedures.

Molecular Weight:304,790 Da[Similar Products]

Chromosome Location:Chromosome: 8; NC_000008.10 (133879205..134147143). Location: 8q24

OMIM:188450

3D Structure:ModBase 3D Structure for P01266

Clonality:Monoclonal

Isotype:IgM

Host:Mouse

Specificity:Anti-Thyroglobulin. Murine MAbs recognize human thyroglobulin. Recognize T3 and T4.

Form/Format:1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4

Antigen:Purified human thyroglobulin.

Activity:Ig mg/ml* : 7.4

ELISA Titer**: 1: 25,600

(Note: * Determined by radial immunodiffusionfor several lots of ascites.

**ELISA is an indirect assay againstthyroglobulin on the solid phase. Titers represent endpoint 

dilutions that achieveabsorbance values >= 0.1.)

Stabilizer:None

Preservatives:None. Available on request.

Dilutions Instructions:Dilute in PBS or medium which is identical to that used in the assay system.

Preparation and Storage:These antibodies are stable for at leastone (1) year at -20 degree C to -70 degree C.

 Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Other Notes

Small volumes of anti-TG antibody vial(s) may occasionally become entrapped in the seal of the product vial 

during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any

 liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Product Categories/Family for anti-TG antibody

Hormone and Serum Protein Antibodies:Applications Tested/Suitable for anti-TG antibody

Immunoassay

Application Notes for anti-TG antibody:These antibodies may be used inimmunoassays to detect 

and quantitatethyroglobulin. Other applications areunder investigation.

NCBI/Uniprot data below describe general gene information for TG. It may not necessarily be applicable to this product.

NCBI GI #:37174

NCBI GeneID:7038

NCBI Accession #:CAA29104.1[Other Products]

UniProt Primary Accession #:P01266[Other Products]

UniProt Secondary Accession #:O15274; O43899; Q15593; Q15948; Q9NYR1; Q9NYR2; Q9UMZ0; Q9UNY3[Other Products]

UniProt Related Accession #:P01266; Q59GF0; Q9NYD9; Q9NYM1[Other Products]

NCBI Official Full Name:thyroglobulin

NCBI Official Synonym Full Names:thyroglobulin

NCBI Official Symbol:TG  

NCBI Official Synonym Symbols:TGN; AITD3  

NCBI Protein Information:thyroglobulin; OTTHUMP00000227159

UniProt Protein Name:Thyroglobulin

Protein Family:Thyroglobulin

UniProt Gene Name:TG  [Similar Products]

UniProt Entry Name:THYG_HUMAN

NCBI Summary for TG

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. 

It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of 

the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic 

reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. 

Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated

 with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with

 susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.

 [provided by RefSeq]

UniProt Comments for TG

TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in

 TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, 

causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid

 dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have 

a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine 

T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain 

and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations 

in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) 

and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases,

 which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the

 type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity

Biological Process: regulation of myelination; iodide transport; thyroid gland development; 

hormone biosynthetic process; signal transduction; thyroid hormone metabolic process

Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3

Research Articles on TG

1. Patients with detectable Tg during the last (1)(3)(1)I treatment and a negative post-therapeutic 

WBS have significant earlier and more recurrences than patients without detectable Tg.

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