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2025.02.01 00:03

[My Biosource 공식 대리점]-anti-TG antibody :: Mouse Thyroglobulin Monoclonal Antibody,anti-TG 항체 :: 마우스 항-인간 티로글로불린 단일클론 항체( MBS190445)

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anti-TG antibody :: Mouse Thyroglobulin Monoclonal Antibody

CATALOG # : MBS190445

Product Name:Thyroglobulin (TG), Monoclonal Antibody 
Full Product Name:Thyroglobulin (T3/T4) Monoclonal Antibody
Product Synonym Names:Anti-Thyroglobulin; Thyroglobulin
Product Gene Name:anti-TG antibody[Similar Products]
Research Use Only:For Research Use Only. Not for use in diagnostic procedures.

Molecular Weight:304,790 Da[Similar Products]
Chromosome Location:Chromosome: 8; NC_000008.10 (133879205..134147143). Location: 8q24
OMIM:188450
3D Structure:ModBase 3D Structure for P01266
Clonality:Monoclonal
Isotype:IgG1
Host:Mouse
Specificity:Anti-Thyroglobulin [Murine MAbs recognize human thyroglobulin. T4-specific]
Form/Format:1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4
Antigen:Purified human thyroglobulin.
Activity:Ig mg/ml* :13.1
ELISA Titer**:1: 51,200
(Note: * Determined by radial immunodiffusionfor several lots of ascites.
**ELISA is an indirect assay againstthyroglobulin on the solid phase. Titers represent endpoint dilutions 
that achieveabsorbance values >= 0.1.)
Stabilizer:None
Preservatives:None. Available on request.
Dilutions Instructions:Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage:These antibodies are stable for at leastone (1) year at -20 degree C to -70 degree C. 
Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Other NotesSmall volumes of anti-TG antibody vial(s) may occasionally become entrapped in the seal of the product
 vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid 
in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Product Categories/Family for anti-TG antibody:Hormone and Serum Protein Antibodies
Applications Tested/Suitable for anti-TG antibody:Immunoassay
Application Notes for anti-TG antibody:These antibodies may be used inimmunoassays to detect and quantitatethyroglobulin.
 Other applications areunder investigation.

NCBI/Uniprot data below describe general gene information for TG. It may not necessarily be applicable to this product.
NCBI GI #:37174
NCBI GeneID:7038
NCBI Accession #:CAA29104.1[Other Products]
UniProt Primary Accession #:P01266
UniProt Secondary Accession #:O15274; O43899; Q15593; Q15948; Q9NYR1; Q9NYR2; Q9UMZ0; Q9UNY3
UniProt Related Accession #:P01266; Q59GF0; Q9NYD9; Q9NYM1 
NCBI Official Full Name:thyroglobulin
NCBI Official Synonym Full Names:thyroglobulin
NCBI Official Symbol:TG  
NCBI Official Synonym Symbols:TGN; AITD3  
NCBI Protein Information:thyroglobulin; OTTHUMP00000227159
UniProt Protein Name:Thyroglobulin
Protein Family:Thyroglobulin
UniProt Gene Name:TG  
UniProt Entry Name:THYG_HUMAN
 
NCBI Summary for TG
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate
 for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone 
and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine
 biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter,
 and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated 
with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
 [provided by RefSeq, Nov 2009]

UniProt Comments for TG
TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are 
the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large
 goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction 
varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively
 high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. 
The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, 
which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are
 associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) 
and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases,
 which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to 
the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity

Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone 
biosynthetic process; signal transduction; thyroid hormone metabolic process

Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3
Research Articles on TG
1. Patients with detectable Tg during the last (1)(3)(1)I treatment and a negative post-therapeutic WBS have 
significant earlier and more recurrences than patients without detectable Tg.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, 
therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to 
MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with 
industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order
 where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, 
MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the
 right to make changes to this datasheet at any time without prior notice.It is the responsibility of the
 customer to report product performance issues to MyBioSource within 30 days of receipt of the product. 
Please visit our Terms & Conditions page for more information.
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