Tumor Cell Lines - M-07e

M-07e cell line was established from the peripheral blood of a 6-month-old girl with acute megakaryoblastic leukemia (AML M7) at diagnosis in 1987; Subline of the growth factor-independent cell line M-07; M-07e cells respond proliferatively to GM-CSF, IFN-alpha, IFN-ß, IFN-gamma, IL-2, IL-3, IL-4, IL-6, IL-15, NGF, SCF, TNF-alpha, TPO.

Product Code:M-07E; M-O7e; M07-e; M07e; Mo7e; MO7e; M07E; MO7E

Species:Human

Cat.No:ABC-TC1313

Product Category:Tumor Cell Lines

Size/Quantity:1 vial

Shipping Info:Dry Ice

Growth Conditions:37 ℃, 5% CO2

Disease:Acute Megakaryoblastic Leukemia

Biosafety Level:1

Storage:Liquid Nitrogen

Product Type:Human Leukemia Cell Lines

Description:The M-07e cell line is a human acute megakaryoblastic leukemia (AML M7) subline. It was established in 1987 from the peripheral blood of a 6-month-old Caucasian female patient and is derived from the M-07 parental line. M-07e cells rely on interleukin-3 (IL-3) or granulocyte-macrophage colony-stimulating factor (GM-CSF) for proliferation. These cells exhibit responsiveness to a wide range of cytokines, encompassing GM-CSF, interferons (IFNs), interleukins (ILs), nerve growth factor (NGF), stem cell factor (SCF), tumor necrosis factor-α (TNF-α), and thrombopoietin (TPO). Prolonged culture may give rise to cytokine-independent subclones. In animal models, M-07e cells do not demonstrate tumorigenic or metastatic potential.

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