anti-CD207 antibody :: Mouse anti-Human Langerin Monoclonal Antibody

CATALOG # : MBS370265

Product Name:Langerin (CD207), Monoclonal Antibody 

Full Product Name:Langerin

Product Gene Name:anti-CD207 antibody[Similar Products]

Research Use Only:For Research Use Only. Not for use in diagnostic procedures.

Molecular Weight:36,725 Da

Chromosome Location:Chromosome: 2; NC_000002.11 (71057343..71062953, complement). Location: 2p13

OMIM:604862

3D Structure:ModBase 3D Structure for Q9UJ71

Clonality:Monoclonal

Isotype:IgG2b

Clone Number:12D6

Host:Mouse

Species Reactivity:Human

Preparation and Storage:Store at 2 to 8 degree C in the dark.

ISO Certification:Manufactured in an ISO 13485:2016 Certified Laboratory.

Other Notes: Small volumes of anti-CD207 antibody vial(s) may occasionally become entrapped 

in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the 

vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may 

require to ship with dry ice and additional dry ice fee may apply.

NCBI/Uniprot data below describe general gene information for CD207. It may not necessarily

 be applicable to this product.

NCBI GI #:6523279

NCBI GeneID:50489

NCBI Accession #:CAB62403.1

UniProt Primary Accession #:Q9UJ71

UniProt Related Accession #:Q9UJ71

NCBI Official Full Name:langerin

NCBI Official Synonym Full Names:CD207 molecule, langerin

NCBI Official Symbol:CD207  

NCBI Official Synonym Symbols:CLEC4K  

NCBI Protein Information

C-type lectin domain family 4 member K; CD207 antigen, langerin; Langerhans cell specific 

c-type lectin; C-type lectin domain family 4, member K

UniProt Protein Name:C-type lectin domain family 4 member K

UniProt Synonym Protein Names:Langerin

Protein Family:C-type lectin domain family

UniProt Gene Name:CD207  

UniProt Synonym Gene Names:CLEC4K  

UniProt Entry Name:CLC4K_HUMAN

NCBI Summary for CD207

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic 

cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the 

cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type 

lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein 

leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-

processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding 

activity. [provided by RefSeq, Aug 2010]

UniProt Comments for CD207

Function: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation

 of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds 

to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake 

of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major 

receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur.

 Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures 

present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the 

Birbeck granules leading to its rapid degradation. Ref.1 Ref.6 Ref.8 Ref.9

Subunit structure: Homotrimer. Ref.4

Subcellular location: Membrane; Single-pass type II membrane protein. Note:

 Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes. Ref.1

Tissue specificity: Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant 

ependymoma, but not in normal brain tissues. Ref.1 Ref.8

Domain: The C-type lectin domain mediates dual recognition of both sulfated and mannosylated glycans. Ref.8

Involvement in disease: Birbeck granule deficiency (BIRGD) [MIM:613393]: A condition characterized by the 

absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans 

cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting 

capacity.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11 Ref.12

Sequence similarities: Contains 1 C-type lectin domain.

Research Articles on CD207

1. binding properties of langerin

Precautions

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 therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to 

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with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process

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