Anti-UBB antibody (STJ11100077)

GENERAL INFORMATION

Host:Rabbit

Applications:WB/DB/ELISA

Reactivity:Mouse/Rat

Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

PRODUCT PROPERTIES

Clonality :Polyclonal

Conjugation:Unconjugated

Isotype:IgG

Formulation:PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.

Purification:Affinity purification

Concentration:Lot specific

Dilution Range:WB:1:500-1:2000

DB:1:500-1:1000

ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.

Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Specificity:A synthetic peptide corresponding to a sequence containing polyubiquitinated protein (K6 linkage).

Background :Polyubiquitin chains regulate diverse cellular processes through the ability of ubiquitin to form chains of eight different linkage types. Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair. it has been reported that modification at Lys-6 inhibits ubiquitin-dependent protein degradation, a failure of the ubiquitin-proteasome system could play a role in initiating the formation of degradation-resistant PHF tangles.

Information sourced from Uniprot.org

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