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[Focus Biomolecules 공식 대리점]-RMC-7977 | KRAS inhibitor,RMC-7977 | KRAS 억제제(10-3954) CAS:2765082-12-8
- AI바이오허브 오래 전 2025.01.30 22:47 Bulletin Board 인기
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RMC-7977 | KRAS inhibitor
RMC-7977 (2765082-12-8) is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1 It binds with high affinity to cyclophilin A (KD = 195 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 85 nM for G12V). Active in in vivo xenograft models of NSCLC, CRC, and PDAC.1,2,3 RMC-7977 was able to overcome resistance to the KRASG12D selective inhibitor MRTX1133.1
RMC-7977 (2765082-12-8)는 돌연변이 및 야생형 KRAS, NRAS, HRAS 변이체 모두에 대한 광범위 억제제입니다. Cyclophilin A에 높은 친화력으로 결합하여(KD = 195 nM), KRAS 활성 상태에 높은 친화력을 가지는 이중 복합체를 형성합니다(KD = 85 nM for G12V). NSCLC, CRC, PDAC의 생체 내 이종 이식 모델에서 활성을 보이며, RMC-7977은 KRASG12D 선택적 억제제 MRTX1133에 대한 저항성을 극복할 수 있었습니다.
CAS:2765082-12-8
Catalog Number:10-3954
Activity:KRAS inhibitor
Chemical Names:
(1R,5S)-N-[(7S,13S)-20-[5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl]-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetrazapentacyclo[17.5.2.12,5.19,13.022,26]octacosa-1(25),2,5(28),19,22(26),23-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide
Molecular Weight:865.11
Molecular Formula:C47H60N8O6S
Solubility:Soluble in DMSO (>75 mg/ml)
Physical Properties:Yellow solid
Purity:>98% HPLC
NMR: (Conforms)
Storage Temperature:-20°C
Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 1 months.
Shipping Code:RT
