CD8 a (ABT304) Mouse mAb-YM6938

Target:CD8

Host Species:Mouse

Reactivity:Human,

Applications:IHC, IF, ELISA

MW:26kD (Calculated);30-35kD (Observed)

Conjugate/Modification:Unmodified

DETAILED INFORMATION

Recommended Dilution Ratio:IHC 1:200-400; IF 1:200-1:1000; ELISA 1:500-5000

Formulation:PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Specificity:The antibody can specifically recognize human CD8 protein, including two typies of dimer: αβ heterodimer or αα homodimer.

Purification:The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

Storage:-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Calculated):26kD

MW(Observed):30-35kD

Modification:Unmodified

Clonality:Monoclonal

Clone Number:ABT304

Isotype:IgG2b,Kappa

ANTIGEN AND TARGET INFORMATION

Immunogen:Synthesized peptide derived from human CD8 AA range: 100-235

Specificity:The antibody can specifically recognize human CD8 protein, including two typies of dimer: αβ heterodimer or αα homodimer.

Gene Name:CD8A MAL

Protein Name:alpha polypeptide (p32);CD_antigen=CD8a;CD8;CD8 antigen alpha polypeptide;CD8 antigen alpha polypeptide (p32);CD8 antigen, alpha polypeptide (p32);CD8a;CD8A antigen;CD8A

Other Name:alpha polypeptide ;p32 ;CD_antigen=CD8a ;

Database Link

Organism:Human

Gene ID:925

SwissProt:P01732

Background:

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],

Function:

Disease:Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.,Function:Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.,online information:CD8 entry,online information:CD8A mutation db,PTM:All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterdimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.,

Cellular Localization:Membranous

Tissue Expression:Tonsil/ Appendix

Research Areas:>>Cell adhesion molecules ;>>Antigen processing and presentation ;>>Hematopoietic cell lineage ;>>T cell receptor signaling pathway ;>>Yersinia infection ;>>Primary immunodeficiency

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