CaCCInh-A01 (407587-33-1) is a potent inhibitor of TMEM16A (IC50 = 2.1 mM), a calcium-activated chloride channel1. Blockade of TMEM16A with CaCCInh-A01 protects against renal fibrosis2, reduces blood brain barrier permeability, attenuates brain infarct size and neurological deficits after ischemic stroke3, and induces apoptosis and cell cycle arrest in various epithelium-originated cancer cells4.

CaCCInh-A01 (407587-33-1)는 칼슘 활성 염화채널인 TMEM16A(IC50 = 2.1 mM)의 강력한 억제제입니다. CaCCInh-A01로 TMEM16A를 차단하면 신장 섬유증을 방지하고, 혈액 뇌 장벽 투과성을 감소시키며, 허혈성 뇌졸중 후 뇌 경색 크기와 신경 결손을 완화하며, 다양한 상피 유래 암 세포에서 세포 사멸과 세포 주기 정지를 유도합니다.

CAS:407587-33-1

Catalog Number:10-1600

Activity:TMEM16A inhibitor

Chemical Names:6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid

Molecular Weight:347.43

Molecular Formula:C18H21NO4S

Solubility:Soluble in DMSO (40 mg/ml)

Physical Properties:White solid

Purity:>98% TLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:RT

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