Name: 0990CL

MedKoo Cat# : 562975

CAS# : 511514-03-7

Exact Mass: 343.1797

Molecular Weight: 343.43

Elemental Analysis: C, 73.44; H, 6.16; N, 20.39

Related CAS #;No Data

Synonym:0990CL; 0990-CL; 0990 CL;

IUPAC/Chemical Name:(4-Phenyl-quinazolin-2-yl)-(4,6,6-trimethyl-1,6-dihydro-pyrimidin-2-yl)-amine

InChi Key:DXICUHJLOMNKOU-UHFFFAOYSA-N

InChi Code:InChI=1S/C21H21N5/c1-14-13-21(2,3)26-20(22-14)25-19-23-17-12-8-7-11-16(17)18(24-19)15-9-5-4-6-10-15/h4-13H,1-3H3,(H2,22,23,24,25,26)

SMILES Code:CC1(C)C=C(C)N=C(NC2=NC(C3=CC=CC=C3)=C4C=CC=CC4=N2)N1

Appearance:Solid powder

Purity:>98% (or refer to the Certificate of Analysis)

Shipping Condition:Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:Soluble in DMSO

Shelf Life:>2 years if stored properly

Drug Formulation:This drug may be formulated in DMSO

Stock Solution Storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:2934.99.9001

Biological target:0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi.

In vitro activity:TBD

In vivo activity:TBD

Reference:

Appleton KM, Bigham KJ, Lindsey CC, Hazard S, Lirjoni J, Parnham S, Hennig M, Peterson YK. Development of inhibitors of heterotrimeric Gαi subunits. Bioorg Med Chem. 2014 Jul 1;22(13):3423-34. doi: 10.1016/j.bmc.2014.04.035. Epub 2014 Apr 26. PMID: 24818958; PMCID: PMC4103618.

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