A 769662

(HB1351)

Product overview

Name:A 769662

Purity:>98%

Description:Potent, reversible AMPK activator. Inhibits MSC proliferation.

Biological description

Potent reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 µM). Activates AMPK allosterically and inhibits AMPK dephosphorylation. Also Na+ - K+- ATPase inhibitor (IC50 values are 57 and 220 µM for rat and human respectively). Stimulates glucose uptake and decreases fatty acid synthase levels. Additionally shown to inhibit MSC proliferation.

Storage instructions:+4°C

Solubility overview:Soluble in DMSO (100 mM)

Important:This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Chemical Data

Purity:>98%

Chemical name:6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

Molecular Weight:360.39

Molecular Formula:C20H12N2O3S

CAS Number:844499-71-4

PubChem identifier:54708532

SMILES:C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O

InChi:InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25)

InChiKey:CTESJDQKVOEUOY-UHFFFAOYSA-N

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