EGFR Mouse mAb

EM1044

Product name: EGFR Mouse mAb

Reactivity:Human

Alternative Names:Epidermal Growth Factor Receptor ;ErbB-1; ErbB1; ER1; ERB-B1; MENA; HER1; Erythroblastic Leukemia

Viral(v-Erb-B)oncogene Homolog,Avian; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1

Source: Mouse

Dilutions:WB 1:1,000 IF 1;100-200  IHC 1:200-500

Immunogen:Synthetic Peptide

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration: 1mg/mL

Observed Band:170kDa

GeneID:1956

Human Swiss-Prot No: P00533

Cellular localization:Secreted and Cell membrane. Endoplasmic reticulum membrane

Background:The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the 

epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, 

epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or 

heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like 

GRB2 which in turn activates complex downstream signaling cascadesβ-Actin is one of six different actin isoforms that have been 

identified. The actin molecules found in cells of various species and tissues tend to be very similar in their immunological and physical 

properties. Therefore, Antibodies against β-Actin are useful as loading controls for Western Blotting. However it should be noted that 

levels of β-Actin may not be stable in certain cells. For example, expression of β-Actin in adipose tissue is very low and therefore 

β-Actin should not be used as loading control for these tissues.

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