SW033291 | 15-PGDH inhibitor

CAS:459147-39-8

Catalog Number:10-4888

SW033291 (459147-39-8) is an inhibitor of 15-hydroxyprostaglandin dehydrogenase (IC50 = 1.5 nM) that increases prostaglandin 

E2 levels in bone marrow and other tissues by inhibiting in vivo degradation of PGE2.

1. It accelerated neutrophil recovery, regeneration of platelets and red blood cells, and expanded the numbers of more primitive bone marrow 

SKL cells in bone marrow transplants. SW033291 also stimulated colon epithelial regeneration in a mouse model of ulcerative colitis. 

It increased bone formation in mice via PGE2 activation of EP4.

2. SW033291 enhanced myogenic differentiation and myotube formation in repairing muscle defects in mice.

3. It reduced the severity of pulmonary fibrotic lesions and extracellular matrix remodeling and improved pulmonary function in bleomycin-treated mice.

4. It also prevented hepatic ischemia-reperfusion injury in mice.5 SW033291 mitigates oxidative damage, suppresses neuroinflammation, and restores 

blood-brain barrier integrity in mouse models of Alzheimer’s disease and traumatic brain injury.6 In addition to halting neurodegeneration, it also 

preserved cognitive function at levels indistinguishable from healthy controls.

Activity:15-PGDH inhibitor

Chemical Names:4-Butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine

Molecular Weight:412.58

Molecular Formula:C21H20N2OS3

Solubility:Soluble in DMSO (25 mg/ml with warming)

Physical Properties:Yellow solid

Purity:98% HPLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:RT

References/Citations:

1.Zhang et al. (2015), Inhibition of the Prostaglandin Degrading Enzyme 15-PGDH Potentiates Tissue Regeneration; Science, 348 aaa2340

2.Chen et al. (2019), Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis; Nat. Commun., 10 181

3.Dong et al. (2020), Effects of SW033291 on the myogenesis of muscle-derived stem cells and muscle regeneration; Stem Cell Res. Ther., 11 76

4.Smith et al. (2020), Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis; Rep., 10 11657

5.Xie et al. (2022), Effects of small molecule inhibitor SW033291 on hepatic ischemia-reperfusion injury in mice; Biochem. Biophys. Res. Commun., 615 70

6.Koh et al. (2025), Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer’s disease and traumatic brain injury; 

Proc. Natl. Acad. Sci. USA, 122 e2417224122

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