Lactoyl phenylalanine | Anorexigenic circulating metabolite

CAS:183241-73-8

Catalog Number:10-5713

Exercise is associated with transient suppression of appetite which previously has been attributed to induction of appetite-

regulatory hormone such as GLP-11 or the increase in circulating metabolites including L-lactate2. A targeted metabolomics 

approach with blood samples from two independent human exercise studies resulted in the identification of N-lactoyl-phenylalanine 

(Lac-Phe; 183241-73-8) as a highly upregulated circulating metabolite following exercise.3 Lac-Phe was shown, using pharmacological 

and genetic methods, to be an exercise-inducible metabolite that suppresses feeding and obesity. A single injection of Lac-Phe was 

demonstrated to reduce food intake by ~50% in diet-induced obese mice. However, Lac-Phe is completely inactive when administered orally.4

183241-73-8, Lac-Phe, Lac-Phe supplier, Lactoyl phenylalanine, Lactoyl phenylalanine supplier

CAS:183241-73-8

Catalog Number:10-5713

Activity:Anorexigenic circulating metabolite

Chemical Names:N-[(2S)-2-hydroxy-1-oxopropyl]-L-phenylalanine

Alternate Name:Lac-Phe

Molecular Weight:237.26

Molecular Formula:C12H15NO4

Solubility:Soluble in DMSO (>50 mg/ml with warming)

Physical Properties:White solid

Purity:>98% HPLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:RT

References/Citations:

1.Hazell et al. (2016), Effects of exercise intensity on plasma concentrations of appetite-regulating hormones: Potential mechanisms; Appetite, 98 80

2.McCarthy et al. (2020), The emerging role of lactate as a mediator of exercise-induced appetite suppression; J. Endocrinol. Metab., 319 E814

3.Lund et al. (2022), Outrunning obesity with Lac-Phe?; Cell Metab., 34 P1085

4.Li et al. (2022), An exercise-inducible metabolite that suppresses feeding and obesity; Nature, 606 785

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