AqB013 | Aquaporin blocker

CAS:1021869-51-1

Catalog Number:10-5723

AqB013 (1021869-51-1) is a selective aquaporin-1 and -4 inhibitor (IC50 ~ 20 mM) which acts at the cytoplasmic 

side of the AQP water pore.1 It blocks cGMP-stimulated human retinal pigment epithelium fluid transport.2 In HT29 

colon cancer cells AqB013 restricted migration and invasiveness and prevented endothelial tube formation.3,4 

It reduces the invasiveness of U87-MG and U251-MG glioblastoma cells in vitro.5

1021869-51-1, AqB013, AqB013 supplier, aquaporin blocker

CAS:1021869-51-1

Catalog Number:10-5723

Activity:Aquaporin blocker

Chemical Names:3-(Butylamino)-4-phenoxy-N-(pyridine-4-yl)-5-sulfamoylbenzamide

Alternate Name:Sotorasib

Molecular Weight:440.52

Molecular Formula:C22H24N4O4S

Solubility:Soluble in DMSO (30 mg/ml)

Physical Properties:Off-white solid

Purity:>98% TLC

NMR (Conforms)

Storage Temperature:-20°C

Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:RT

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