Senexin B | CDK8/19 inhibitor

CAS:1449228-40-3

Catalog Number:10-4863

Senexin B (1449228-40-3) is a potent inhibitor of cyclin-dependent kinases 8 and 19.1 It suppressed tumor growth 

and augmented the effects of fulvestrant in ER-positive breast cancer xenografts. KD50s: CDK8 = 59 nM, CDK19 = 23 

nM.2 Senexin B also showed synergistic effects with lapatinib and trastuzumab in a panel of HER2+ breast cancer 

cell lines. Senexin B and ALK5 inhibitor SB431542 afforded generation of pancreatic islet cells from pluripotent stem 

cells without any mutagenic effects.4 Combination treatment of Senexin B and Imatinib intensified apoptotic cell 

death in chronic myelogenous leukemia cells and prevented quiescence-mediated escape from apoptosis.5

1449228-40-3, BCD-115, CDK19 inhibitor, CDK8 inhibitor, CDK8/19 inhibitor, Senexin B, Senexin B supplier

CAS:1449228-40-3

Catalog Number:10-4863

Activity:CDK 8/19 inhibitor

Chemical Names:4-[2-[6-(4-Methylpiperazine-1-carbonyl)naphthalen-2-yl]ethylamino]quinazoline-6-carbonitrile

Alternate Name:BCD-115

Molecular Weight:450.55

Molecular Formula:C27H26N6O

Solubility:Soluble in DMSO (>25 mg/ml)

Physical Properties:Off-white solid

Purity:>98% HPLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:RT

References/Citations:

1.McDermott et al. (2017), Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth 

of estrogen receptor positive breast cancer; Oncotarget 8 12558

2.Chen et al. (2019); Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 In Not Due to Target Inhibition, Cells, 8 1413

3.Ding et al. (2022); Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these 

agents in vitro and in vivo, Proc. Natl. Acad. Sci. USA, 119 e2201073119

4.Sakuma et al. (2023); CDK8/19 inhibition plays an important role in pancreatic ß-cell induction from human iPSCs, Stem Cell Res. Ther., 14 1

5.Khamidullina et al. (2025); CDK8/19 inhibition attenuates G1 arrest induced by BCR-ABL antagonists and accelerates death of chronic myelogenous leukemia cells, Cell Death Discov., 11 62

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