PCNA Mouse mAb

EM1030

Product name:PCNA Mouse mAb

Reactivity:Human, Rat, Mouse

Source: Mouse

Dilutions:WB 1:5,000 IHC 1:200

Immunogen:Synthetic Peptide

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration: 1mg/mL

Observed Band:29kDa

GeneID:5111

Human Swiss-Prot No: P12004

Cellular localization: Nucleus

Background: PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. It is found in the nucleus and 

is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps increase the processivity of leading strand 

synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6 dependent 

DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of this 

gene have been described on chromosome 4 and on the X chromosome.

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