AT7519 HCl | Multi CDK inhibitor

CAS:902135-91-5

Catalog Number:10-4859

AT7519 (902135-91-5) is a potent CDK inhibitor.  Inhibits CDKs 1,2,4,5,6, and 9 (IC50s respectively: 210 nM, 47nM, 

100 nM, 13 nM, 170 nM, and <10 nM).1,2 Active in multiple human cancer cell lines.3-7 AT7519 has also been found 

to be a human RORγt agonist.8

902135-91-5, AT-7519, AT7519, AT7519 HCl, AT7519 hydrochloride, AT7519 supplier, CDK inhibitor

CAS:902135-91-5

Catalog Number:10-4859

Activity:Multi CDK inhibitor

Chemical Names:4-[(2,6-Dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide hydrochloride

Molecular Weight:418.70

Molecular Formula:C16H17Cl2N5O2·HCl

Solubility:Soluble in DMSO (>25 mg/ml)

Physical Properties:White solid

Purity:>98% HPLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:RT

References/Citations:

Wyatt et al. (2008), Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), 

a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design; 

J. Med. Chem. 51 4986

Squires et al. (2009); Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human

tumor cell lines, Mol. Cancer Ther., 8 324

Do et al. (2020); Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients 

with advanced solid tumors, Cancer Chemother. Pharmacol., 86 815

Wang et al. (2022); The cyclin-dependent kinase inhibitor AT7519 augments cisplatin’s efficacy in ovarian cancer via multiple 

oncogenic signaling pathways, Fundam. Clin. Pharmacol., 36 81

Zhou et al. (2022); AT7519 against lung cancer via the IL6/STAT3 signaling pathway, Biochem. Biophys. Res. Commun., 609 31

Zhao et al. (2023); The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and 

cell cycle arrest, Cell Death Dis., 14 11

Karas et al. (2023); Anti-hepatocellular carcinoma activity of the cyclin-dependent kinase inhibitor AT7519, Biomed. 

Pharmacother., 164 115002

Karas et al. (2025), The cyclin-dependent kinase inhibitor AT7519 is a human RORγt agonist; Immunol. Cell Biol. 103 317

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