DMB (281209-71-0) is a small molecule glucagon-like peptide 1 (GLP-1) ago-allosteric modulator and agonist (EC50 = 101 nM).

1 It significantly stimulated insulin secretion in BRIN-BD11 cells and decreased overall glucose excursion in mice.

2  DMB is a direct and selective gasdermin D (GSDMD) agonist that activates GSDMD pore formation and pyroptosis 

without cleaving GSDMD (EC50 = 700 nM).

3 It induced pyroptosis in mouse cancer cell lines and induced tumor regression and enhanced antitumor immunity.  

DMB-treated tumor cells acted as a tumor vaccine in mice indicating that DMB can trigger immunogenic cell death 

that provides protective antitumor immunity.

281209-71-0, DMB gasdermin, DMB gasdermin D agonist, DMB GLP-1 agonist, DMB supplier, gasdermin agonist, Gasdermin D agonist

CAS:281209-71-0

Catalog Number:10-3975

Activity:Gasdermin D agonist/GLP-1 agonist

Chemical Names:6,7-Dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline

Molecular Weight:348.20

Molecular Formula:C13H15Cl2N3O2S

Solubility:

Soluble in DMSO (30 mg/ml with warming)

Physical Properties:

Yellow solid

Purity:98% HPLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:RT

References/Citations:

Knudsen et al. (2007), Small-molecule agonists for the glucagon-like peptide 1 receptor; Proc. Natl. Acad. Sci. USA 104 937

Irwin et al. (2010), Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline; Eur. J. Pharmacol. 628 268

Fontana et al. (2024), Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity; Cell 187 6165

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