NR2E3 agonist 11a | NR2E3 agonist

CAS:911211-69-3

Catalog Number:10-4866

11a (911211-69-3) is an agonist of the photoreceptor-specific nuclear receptor (NR2E3; PNR; RNR), found in rod 

photoreceptor cells (EC50 = 141 nM ß-lactamase assay; 35 nM NCOR assay).1  An interesting tool for targeting 

age-related macular degeneration.  11a was able to increase p53 activation in uterine cancer tumors suggesting 

NR2E3 agonism as a new anti-cancer strategy.2 A previous study found that cytotoxicity of 11a was due to G1/S 

phase cell cycle arrest rather than NR2E3 agonism.3

Activity:NR2E3 agonist

Chemical Names:2-Chloro-N-[4-[6-(cyclopropanecarbonylamino)-1H-benzimidazol-2-yl]phenyl]benzamide

Molecular Weight:430.89

Molecular Formula:C24H19ClN4O2

Solubility:Soluble in DMSO (30 mg/ml)

Physical Properties:Pale yellow solid

Purity:>98% TLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:RT

References/Citations:

Wolkenberg et al. (2006), Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a 

radioligand; Bioorg. Med. Chem. Lett., 16 5001

Wang et al. (2025), Orphan nuclear receptor NR2E3 is a new molecular vulnerability in solid tumors by activating p53; Cell Death Dis., 

16 15

Zhao et al. (2013), Systematic Analyses of the Cytotoxic Effects of Compound 11a, a Putative Synthetic Agonist of Photoreceptor-Specific 

Nuclear Receptor (PNR), in Cancer Cell Lines; PLoS One, 8 e75198