Hydroxyl PEG Succinimidyl Carboxymethyl Ester

SKU: HO-PEG-SCM

Categories: Heterobifunctional Linear PEGs, Heterobifunctional PEGs with Carboxyl and Activated Carboxyl (NHS), 

PEGs WITH HYDROXYL, PEGs WITH NHS ESTER

Description

High quality Hydroxyl PEG Succinimidyl Carboxymethyl Ester with standard quality specification of ≥95% Substitution.

Heterobifunctional Hydroxyl PEG Succinimidyl Carboxymethyl Ester products from JenKem Technology are generally 

employed as crosslinking agents or as spacers between two different chemical entities. The PEG moiety in the heterofunctional 

PEG derivatives provides water solubility, biocompatibility, and flexibility. Applications are especially geared towards the 

development of antibody drug conjugates (ADC’s).

Heterobifunctional PEGylation reagents with molecular weights, branching, and functional groups not listed in our online 

catalog may be available by custom synthesis. Please inquire at tech@jenkemusa.com about pricing and availability of 

custom PEGs.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing

References:

Wang, Y., et al., A pH-responsive silica–metal–organic framework hybrid nanoparticle for the delivery of hydrophilic drugs, 

nucleic acids, and CRISPR-Cas9 genome-editing machineries, Journal of Controlled Release, 2020.

Dutta, R., et al., Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice, 

Pharmaceutical research, 2017, 34(3):564-78.

Jaskula-Sztul, R., et al., Thailandepsin A-loaded and octreotide-functionalized unimolecular micelles for targeted neuroendocrine 

cancer therapy, Biomaterials, 2016, 91:1-0.

Chen, G., et al., KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted 

neuroendocrine cancer therapy, Biomaterials, 2016, 97, p. 22-33.

Liang, K., et al., Peptide-Tunable Drug Cytotoxicity via One-Step Assembled Polymer Nanoparticles, Advanced Materials, 

2014, 26(15), p: 2398–2402.

Xu, W., Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer, 

Biomaterials, 2013, 34(21) p: 5244-5253.

Lak, A., et al., Highly stable monodisperse PEGylated iron oxide nanoparticle aqueous suspensions: a nontoxic tracer for 

homogeneous magnetic bioassays, Nanoscale, 2013, 5, p: 11447-11455.

Xu, W., et al., Octreotide-functionalized and resveratrol-loaded unimolecular micelles for targeted neuroendocrine cancer 

therapy, Nanoscale, 2013, 5.20 : 9924-9933.

Note: Starting July 2016, Hydroxyl PEG Succinimidyl Carboxymethyl Ester is the new name of the product Hydroxyl PEG NHS 

(MW 2000 (HO-PEG2000-NHS), MW 3500 (HO-PEG3500-NHS) MW 5000 (HO-PEG5000-NHS) and MW 7500 (HO-PEG7500-NHS)).

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development 

and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and 

services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. 

The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability 

for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical 

device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.