OTUDin3 | OTUD3 inhibitor

CAS:441290-65-9

Catalog Number:10-4981

OTUDin3 (441290-65-9) is a potent inhibitor of the deubiquitinase OTUD3, a member of the ovarian tumor proteases 

which plays a key role in tumorigenesis, neurodegeneration, metabolism, and immunity.  It inhibited non-small cell lung 

cancer growth, migration, and invasion via enhancing the ubiquitination and degradation of the anti-apoptotic protein 

GRP78.  OTUDin3 inhibited lung cancer growth in an H1299 mouse xenograft model.

Activity:

OTUD3 inhibitor

Chemical Names:N-[3-(1H-Benzimidazol-2-yl)phenyl]-4-[(3,4-dihydro-2(1H)-isoquinolinyl)sulfonyl]benzamide

Alternate Name:N/A

Molecular Weight:508.60

Molecular Formula:C29H24N4O3S

Solubility:Soluble in DMSO (40 mg/ml)

Physical Properties:White to off-white solid

Purity:>98% by HPLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:RT

Safety Data Sheet:N/A

References/Citations:

Zhang, et al. (2023), Discovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer; Cell Death Dis., 14 378