Anti-2019-nCoV S-IgM Neutralizing Antibody (8A5)

Catalog# : EPT006

Product name:Anti-2019-nCoV S-IgM Neutralizing Antibody (8A5)

Description:The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus

 to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome 

(SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can 

mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a 

target for entry inhibitors. It's been reported that SARS-CoV-2 can infect the human respiratory epithelial 

cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane

 protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is 

responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane 

fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well 

as protective immunity.

Biological activity:Immobilized 2019-nCoV S Protein RBD-SD1-His(Cat#DRA42)at 2μg/ml (100μl/well) 

can bind Anti-2019-nCoV S-IgM Neutralizing Antibody (8A5)(Cat#DA039). The ED50 of Anti-2019-nCoV 

S-IgM Neutralizing Antibody (8A5)(Cat#DA039)is 18.5 ng/ml.

Storage:24 months from manufacturing at <-20 °C; 1 month, 2 to 8 °C under sterile conditions.

Delivery condition:The product is shipped on dry ice pack.Upon receipt, store it immediately at the 

temperature listed below.

Background:The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus 

to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome 

(SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can 

mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and 

a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial 

cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane

 protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is 

responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane 

fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, 

as well as protective immunity.