FLI-06 | Notch pathway inhibitor

CAS: 313967-18-9

Catalog Number:10-1504

FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-

independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from 

that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a 

tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early 

stage in secretory traffic.1

Activity:Notch pathway inhibitor

Molecular Weight:438.52

Molecular Formula:C25H30N2O5

Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).

Physical Properties:Yellow solid

Purity:98% by TLC

NMR (Conforms)

Storage Temperature:-20°

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.

Shipping Code:RT

Safety Data Sheet:N/A

Product Data Sheet:Download Product Data Sheet

References/Citations:

1) Kramer et al., (2013), Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol. 9 731