MGD-28

CAS# 2991818-13-2

MedKoo CAT#: 556386

Description: MGD-28 is a potent molecular glue degrader that demonstrates significant in vitro efficacy against 

various hematological cancer cell lines. It induces degradation of Ikaros family zinc finger proteins 1, 2, and 3 

(IKZF1/2/3) and casein kinase 1 alpha (CK1α) with nanomolar potency via a Cullin-cereblon (CRBN) dependent pathway. 

Compared to lenalidomide and pomalidomide, MGD-28 achieves deeper, faster, and more potent degradation of these 

neosubstrates. Additionally, MGD-28 exhibits broad antiproliferative activity in multiple solid malignancies and shows 

preferential cytotoxicity toward multiple myeloma patient-derived cells at various disease stages.

Chemical Formula: C33H34FN7O3

Exact Mass: 595.27

Molecular Weight: 595.679

Elemental Analysis: C, 66.54; H, 5.75; F, 3.19; N, 16.46; O, 8.06