Product Information

Product Name:Selank peptide (TFA removed)

Catalog#300018

 Documents:

1.COA/MS/HPLC Report

2.Handling and Storage of Synthetic Peptides

3.Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Sequence Shortening:TKPRPGP

Sequence:Thr-Lys-Pro-Arg-Pro-Gly-Pro

Length:7

Peptide Purity (HPLC):99.42%

Molecular Formula:C33H57N11O9

Molecular Weight:751.87

CAS No.:129954-34-3

Source:Synthetic

Form:Powder

Description:

Selank is a synthetic analog of the endogenous tuftsin molecule (the short Thr-Lys-Pro-Arg fragment of 

the human immunoglobulin G heavy chain), which was elongated at the C terminus via the addition of three natural 

L-amino acids (Pro-Gly-Pro) to improve its metabolic stability and yield a relatively longer duration.

Selank has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and antistress 

drug that relieves aggression and fear reaction in different animal species. It also has a nootropic action, which 

positively influences the formation of memory and learning processes, and marked immunomodulatory activity.

Selank is also named: Selanc. Chronic administration of the neuropeptide Selank (TKPRPGP) to juvenile rats 

significantly prolongs the expression of nestin and doublecortin in the olfactory bulbs. Nestin expression 

remains elevated for up to 35 days, while doublecortin expression persists for up to 74 days post-treatment. 

In contrast, adult rats treated with TKPRPGP do not exhibit a re-expression of these neuronal progenitor markers.

Storage Guidelines:

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer 

at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

References:

Kost NV, Sokolov OIu, Gabaeva MV, et al. [Semax and selank inhibit the enkephalin-degrading 

enzymes from human serum]]. Bioorg Khim. 2001;27(3):180-3.

Zolotarev IuA, Dadaian AK, Dolotov OV, et al. Bioorg Khim. 2006;32(2):183-191.

About TFA Salt:

Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis 

process.

TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), 

and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. 

At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations 

(as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator

 on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially 

unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

Peptide Property

Analysed Sequence:H-TKPRPGP-OH

Chemical Formula:C33H57N11O9

Sequence length:7

Extinction coefficient:0 M-1cm-1

GRAVY:-2.04

Mw average:751.87

Theoretical pI:11.48

Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"