C2230 | Cav2.2 channel blocker 

CAS:882243-88-1

Catalog Number:10-4955

C2230 (882243-88-1) is a novel Cav2.2 channel blocker (IC50 = 1.3 µM @ -50 mV; 10.2 µM @ -80 mV) with a unique 

binding mode (no GPCR-mediated inhibition).  It displays preferential binding to the inactive state of the channel.  

C2230 is active in both rat and human DRG neurons.  Active in rat models of neuropathic pain and mouse models of 

osteoarthritis.  C2230 does not affect somatosensation or motor and cardiac function.

882243-88-1, C-2230, C2230, C2230 supplier, Cav2.2 blocker

CAS:882243-88-1

Catalog Number:10-4955

Activity:Cav2.2 channel blocker

Chemical Names:1-(2-tert-Butyl-4-methoxyphenoxy)-3-(cyclopentylamino)propan-2-ol

Molecular Weight:321.46

Molecular Formula:C19H31NO3

Solubility:Soluble in DMSO (at least 100 mg/ml)

Physical Properties:

White to off-white waxy solid

Purity:>98% TLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. 

Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:RT

References/Citations:

Tang et al. (2024), C2230, a preferential use- and state-dependent Cav2.2 channel blocker, mitigates pain behaviors 

across multiple pain models; J. Clin. Invest. Dec 10 e177429