NA-Gly | GPR18 agonist

CAS: 179113-91-8

Catalog Number:10-1200

NA-Gly (179113-91-8) is an endogenous anti-inflammatory lipo-amino acid.1 Full agonist at GPR18.2,3 Induces 

macrophage apoptosis via GPR184 which may be a mechanism for its resolution of inflammation activity5.

CAS:179113-91-8

Catalog Number:10-1200

Activity:GPR18 agonist

Alternate Names:N-Arachidonylglycine

Chemical Name:N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)glycine

Molecular Weight:361.53

Molecular Formula:C22H35NO3

Solubility:Soluble in DMSO (up to 50 mg/ml).

Physical Properties:Beige waxy solid

Purity:98% by TLC

NMR (Conforms)

Storage Temperature:-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Product is subject to oxidation. Solutions in degassed 

DMSO may be stored at -20°C for up to 1 month.

Shipping Code:Blue Ice

Safety Data Sheet:N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or 

veterinary applications.Please note that we do not sell to individuals and that all orders placed by non-research 

organizations will incur a $20 restocking/refund fee

References/Citations:

1) Huang et al. (2001), Identification of a new class of molecules, the arachidonyl amino acids, and characterization of 

one member that inhibits pain; J. Biol. Chem., 276 42639

2) McHugh et al. (2012), Δ(9)-Tetrahydrocannabinol and N-arachidonylglycine are full agonists at GPR18 receptors 

and induce migration in human endometrial

HEC-1B cells; Br. J. Pharmacol., 165 2414

3) McHugh et al. (2012), siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonyl glycine-

induced cell migration; J. Mol. Signal., 7 10

4) Takenouchi et al. (2012), N-arachidonyl glycine induces macrophage apoptosis via GPR18; Biochem. Biophys. 

Res. Commun., 418 366

5) Burstein et al. (2011), Resolution of inflammation by N-arachidonoylglycine; J. Cell Biochem., 112 3227

6) Console-Bram et al. (2017), N-arachidonoyl glycine, another endogenous agonist of GPR55; Biochem. 

Biophys. Res. Commun., 490 1389 [FOCUS CITATION]