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2025.12.03 16:16

[Focus Biomolecules 한국 공식 대리점 AI Bio Hub [에이아이바이오허브]] 신제품 WX-02-23 | Spliceosome/FOXA1 modulator CAS: 2929223-35-6

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Hot Pick: 지금 가장 주목 받는 제품

WX-02-23 | Spliceosome/FOXA1 modulator

CAS:
 2929223-35-6
Catalog Number:
 10-3969


CrSIEFMsirIcEqnyWamgjhHWfT.png

WX-02-23 (2929223-35-6) is a spliceosome modulator. It binds to the spliceosome factor SF3B1 stabilizing a spliceosome state with enhanced binding to DDX42. WX-02-23 displayed anti-proliferative effects in Panc 05.04 and Panc 04.03 cells.1 WX-02-23 also modulates the pioneer transcription factor FOXA1 via covalent binding to Cysteine 258 in a DNA-dependent manner (EC50 = 2 µM FOXA1; 12 µM FOXA1-FKHD). It alters activity via relaxation of FOXA1s DNA-binding motif changing chromatin accessibility.2

929223-35-6, FOXA1 modulator, SF3B1, SF3B1 binder, Spliceosome modulator, WX-02-23, WX-02-23 supplier, WX0223
Activity:
Spliceosome/FOXA1 modulator
Chemical Names:
(1R,3S)-2-Acryloyl-1-(benzo[d][1,3]dioxol-5-yl)-N-morpholino-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide

Solubility:
Soluble in DMSO (at least 70 mg/ml)
Physical Properties:
Pale yellow solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet


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