Calcium Ionophore A23187 

Catalog Number:HB1000

Product overview

Name:Calcium Ionophore A23187

Alternative names:Calcimycin

Purity:>98%

Description:Non-selective calcium ionophore

Biological description

Non-selective calcium ionophore which facilitates transport of Ca2+ across the plasma membrane.

Increases intracellular Ca2+ concentration to induce Ca2+-dependent cell death. Also increases Zn2+ and Fe2+ permeability across the cell membrane.

Induces ROS and oxidative platelet particle formation.

Also activates IKK2 and NF-κB in mast cells, induces cytokine production and degranulation.

Additionally shown to induce apoptosis and autophagy.

Solubility & Handling

Solubility overview:Soluble in DMSO (50mM) and in ethanol (10mM, gentle warming)

Storage instructions:+4°C (desiccate)

Storage of solutions:Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.

Shipping Conditions:Stable for ambient temperature shipping. Follow storage instructions on receipt.

Important:This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Purity:>98%

Chemical name:5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyr rol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid

Molecular Weight:523.63

Molecular Formula:C29H37N3O6

CAS Number:52665-69-7

PubChem identifier:40486

SMILES:C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)C3=CC=CN3)C)C)O[C@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC

InChi:InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1

InChiKey:HIYAVKIYRIFSCZ-CVXKHCKVSA-N

MDL number:MFCD00151202