MreB Inhibitor A22 | Disrupts bacterial actin cytoskeleton 

CAS:22816-60-0

Catalog Number:10-5275

A22 (22816-60-0) disrupts the actin cytoskeleton of bacteria causing defects in morphology and chromosome segregation.

1 It is a competitive inhibitor of ATP binding to MreB and has the ability to disassemble the actin cytoskeleton in bacterial cells.

1 It displays antibacterial activity against P. aeruginosa (among many others) including multidrug-resistant clinical isolates and 

points to MreB as a new target for antibacterial development.2 A22 significantly disrupts biofilm formation by interfering with 

the ability of bacterial cells to maintain shape and adherence to surfaces.3

CAS:22816-60-0

Catalog Number:10-5275

Activity:Disrupts bacterial actin cytoskeleton

Chemical Names:2-(3,4-Dichloro-benzyl)-isothiourea, hydrochloride

Alternate Name:MreB Perturbing Compound A22

Molecular Weight:271.58

Molecular Formula:C8H8Cl2N2S·HCl

Solubility:Soluble in DMSO (30 mg/ml); Water (6 mg/ml)

Physical Properties:Off-white solid

Purity:>98% HPLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:RT

Safety Data Sheet:Download Safety Data Sheet

Product Data Sheet:Download Product Data Sheet

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References/Citations:

Bean et al. (2009), A22 disrupts the bacterial actin cytoskeleton by directly binding and inducing a low-affinity state in MreB; Biochemistry 48 4852

Bonez et al. (2016), Antibacterial, cyto and genotoxic activities of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride); 

Microb. Pathog. 99 14

Dardaei et al. (2017), Anti-biofilm activity of A22 ((S-3,4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas aeruginosa: 

Influence on biofilm 

formation, motility and bioadhesion; Microb. Pathog. 111 6