Pellitorine | TRPV1 blocker and anti-inflammatory agent

Catalog Number:10-3245

Pellitorine (18836-52-7) is a weak TRPV1 blocker.1 Suppresses lipid accumulation in developing 3T3-L1 adipocytes.2 Inhibits LPS-induced production of TNFα and IL-6 and activation of NFκB in HUVECs at 10 µM.3 Inhibits free fatty acid uptake in Caco-2 cells.4 Inhibits LPS-induced nitric oxide production in RAW264.7 cells (IC50=14.5 µM) exhibiting anti-inflammatory activity by activation of the Nrf2/HO-1 pathway.5

18836-52-7, pellitorine, Pellitorine supplier

CAS:18836-52-7

Catalog Number:10-3245

Activity:TRPV1 blocker and anti-inflammatory agent

Chemical Names:(2E,4E)-N-(2-Methylpropyl)-2,4-decadienamide

Molecular Weight:223.36

Molecular Formula:C14H25NO

Solubility:Soluble in DMSO (30 mg/ml); Ethanol (25 mg/ml)

Physical Properties:White solid

Purity:>98% TLC

NMR: (Conforms)

Storage Temperature:-20°C

Stability:Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:RT

Safety Data Sheet:N/A

References/CItations:

Olah et al. (2017), Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1; Phytomedicine, 34 44

Lieder et al. (2017), The Alkamide trans-Pellitorine Targets PPARγ via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes; Front. Pharmacol., 8 316

Lee et al. (2014), Vascular barrier protective effects of pellitorine in LPS-induced inflammation in vitro and in vivo; Fitoterapia, 92 177

Rohm et al. (2015), Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells; Food Function, 6 173

Ngo et al. (2017), Alkaloids from Piper nigrum Exhibit Antiinflammatory Activity via Activating the Nrf2/HO-1 Pathway; Phytother. Res., 31 663