anti-MHC Class I antibody :: Mouse MHC Class I Monoclonal Antibody 

Catalog #:MBS140072

Product Name:MHC Class I, Monoclonal Antibody 

Full Product Name:Mouse Anti MHC Class I (H-2K)

Product Synonym Names:MHC Class I, H-2K Antibody; MHC Class I, (H-2K) Mouse Antibody

Product Gene Name:anti-MHC Class I antibody

Research Use Only:For Research Use Only. Not for use in diagnostic procedures.

Molecular Weight:26,573 Da

Clonality:Monoclonal

Isotype:IgG2b

Clone Number:NYRmH-2K

Host:Mouse

Specificity:Recognizes most mouse H-2K haplotypes (k,p,q,r,s). Does NOT react with H-2kd.

Purity/Purification:Ion exchange column.

Concentration:1mg/ml in PBS (after reconstitution). (lot specific)

Reconstitution:Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

Immunogen:Purified mouse LN cells (C57Bl/6 anti-BALB/c).

Antibody Properties:Cytotoxic and staining antibody. For staining, use 10ml/1,000,000 cells. Titer for cytotoxicity should be determined by the investigator.

Preparation and Storage:Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.

Other Notes: Small volumes of anti-MHC Class I antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Related Product Information for:anti-MHC Class I antibody

Introduction: MHC Class I is a membrane spanning molecule consisting of 2 proteins. MHC Class I is just about 350 amino acids in length, with roughly 75 amino acids at the carboxylic end comprising the transmembrane and cytoplasmic portions. The remaining 270 amino acids, are divided into three globular domains labeled Alpha-1, Alpha-2 and Alpha-3 prime, with Alpha-1 being closest to the amino terminus and Alpha-3 closest to the membrane. The second portion of the molecule is a small globular protein called Beta-2 Microglobulin It links primarily with the Alpha-3 prime domain and is essential for MHC stability. The MHC ability to show a vast range of antigenic peptides for T cell recognition needs a compromise between broad specificity and high affinity. Both MHC class I and MHC class II show an exceptional structure while the peptide main chain is tightly bound and peptide side chains show less restrictive interactions. It is primarily the peptide side-chain contacts and conformational variability that ensures that the peptide-MHC complex presents an antigenically unique surface to T cell receptors.

Product Categories/Family for anti-MHC Class I antibody:Monoclonal/Polyclonal Antibodies; Monoclonal Antibodies

NCBI/Uniprot data below describe general gene information for MHC Class I. It may not necessarily be applicable to this product.

NCBI GI #:82123757

NCBI Accession #:O98279

NCBI Official Full Name:MHC class I

UniProt Protein Name:MHC class I

UniProt Synonym Protein Names:MHC class I

Protein Family:MHC class I polypeptide-related sequence

UniProt Gene Name:gamr-UA-c24  

UniProt Entry Name:O98279_GADMO

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