Product Name:Pinoresinol diglucoside 

CAS No.:63902-38-5

Catalog No.:CFN99994

Molecular Formula:C32H42O16

Molecular Weight:682.67 g/mol

Purity:>=98%

Type of Compound:Lignans

Physical Desc.:Powder

Source: The barks of Eucommia ulmoides.

Solvent:DMSO, Pyridine, Methanol, Ethanol, etc.

Size /Stock:10 mM * 1 mL in DMSO / In-stock

Other Packaging:*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Description:Pinoresinol diglucoside is a putative α-glucosidase inhibiting compound, has antihypertensive activity. It is a heat shock factor 1 inducer, increased expression of HSF1 by a factor of 1.041 at 3 μM.

Targets:HSF-1 | α-glucosidase

In vitro:

Chem Biodivers. 2013 Jul;10(7):1322-7.

Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents.[Pubmed: 23847077]

The barks of Eucommia ulmoides (Eucommiae Cortex, Eucommiaceae) have been used as a traditional medicine in Korea, Japan, and China to treat hypertension, reinforce the muscles and bones, and recover the damaged liver and kidney functions.

METHODS AND RESULTS:

Among these traditional uses, to establish the recovery effects on the damaged organs on the basis of phytochemistry, the barks of E. ulmoides have been investigated to afford three known phenolic compounds, coniferaldehyde glucoside (1), bartsioside (2), and feretoside (3), which were found in the family Eucommiaceae for the first time. The compounds 1-3 were evaluated for their inducible activities on the heat shock factor 1 (HSF1), and heat shock proteins (HSPs) 27 and 70, along with four compounds, geniposide (4), geniposidic acid (5), Pinoresinol diglucoside (6), and liriodendrin (7), which were previously reported from E. ulmoides. Compounds 1-7 increased expression of HSF1 by a factor of 1.214, 1.144, 1.153, 1.114, 1.159, 1.041, and 1.167 at 3 μM, respectively.

CONCLUSIONS:

Coniferaldehyde glucoside (1) showed the most effective increase of HSF1 and induced successive expressions of HSP27 and HSP70 in a dose-dependent manner without cellular cytotoxicity, suggesting a possible application as a HSP inducer to act as cytoprotective agent.

Source: The barks of Eucommia ulmoides.

Solvent:DMSO, Pyridine, Methanol, Ethanol, etc.

Storage:Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

After receiving:The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.