JH-VIII-157-02 

JH-VIII-157-02 is a potent alk inhibitor. JH-VIII-157-02 can overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation. JH-VIII-157-02 is a structural analogue of alectinib that is potent against the G1202R mutant as well as a variety of other frequently observed mutants. In addition, JH-VIII-157-02 is capable of penetrating the CNS of mice following oral dosing.

MedKoo Cat#: 407894

Name: JH-VIII-157-02

CAS#: 1639422-97-1

Chemical Formula: C28H27N5O2

Exact Mass: 465.2165

Molecular Weight: 465.56

Elemental Analysis: C, 72.24; H, 5.85; N, 15.04; O, 6.87

Related CAS #:No Data

Synonym:JH-VIII-157-02; JH-VIII-15702; JH-VIII-157 02; JHVIII-157-02; JHVIII-15702; JHVIII-157 02; JH815702; JH-815702; JH 815702.

IUPAC/Chemical Name:2-(4-(3-cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)-1H-pyrazol-1-yl)-N,N-dimethylacetamide

InChi Key:InChI=1S/C28H27N5O2/c1-6-17-10-21-22(11-20(17)18-13-30-33(14-18)15-24(34)32(4)5)28(2,3)27-25(26(21)35)19-8-7-16(12-29)9-23(19)31-27/h7-11,13-14,31H,6,15H2,1-5H3

InChi Code:InChI=1S/C28H27N5O2/c1-6-17-10-21-22(11-20(17)18-13-30-33(14-18)15-24(34)32(4)5)28(2,3)27-25(26(21)35)19-8-7-16(12-29)9-23(19)31-27/h7-11,13-14,31H,6,15H2,1-5H3

SMILES Code:O=C(N(C)C)CN1N=CC(C2=C(CC)C=C3C(C(C)(C)C(NC4=C5C=CC(C#N)=C4)=C5C3=O)=C2)=C1

Appearance:Solid powder

Purity:>98% (or refer to the Certificate of Analysis)

Shipping Condition:Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:Soluble in DMSO

Shelf Life:>2 years if stored properly

Drug Formulation:This drug may be formulated in DMSO

Stock Solution Storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:2934.99.9001

REFERENCES 

1: Hatcher JM, Bahcall M, Choi HG, Gao Y, Sim T, George R, Jänne PA, Gray NS. Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase

Resistance Mutation. J Med Chem. 2015 Dec 10;58(23):9296-9308. doi:10.1021/acs.jmedchem.5b01136. Epub 2015 Nov 25. PubMed PMID: 26568289; PubMed

Central PMCID: PMC4907642.

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