Clozapine(HB1607) 

Name:Clozapine

Alternative names:CLZ-ChemoNM

Purity:>99%

Description:Prototypic, atypical antipsychotic, binds to both serotonin and dopamine receptors

Biological description

Clozapine is a prototypic, atypical antipsychotic which binds to both serotonin and dopamine receptors (Ki values are 35, 83 and 22, 250 and 141 nM at D2, D3 and D4, D5, D1 and 12.6 and 13.2 nM at 5-HT2A and 5-HT2C receptors respectively) and also shows activity at other receptors.

Clozapine shows high BBB permeability and is active in vivo. It shows antisychotic, antidepression and anxiolytic activites.

Recently, clozapine (which CNO rapidly converts to) has been indicated to show high DREADD (hM3Dq and hM4Di) affinity and potency. Subthreshold clozapine injections are indicated to induce preferential DREADD-mediated behaviors.

Water soluble version of clozapine also available

Storage instructions:Room temperature

Solubility overview:Soluble in DMSO (100 mM) and in ethanol (50 mM)

Important:This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Purity:>99%

Chemical name:8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Molecular Weight:326

Molecular Formula:C18H19ClN4

CAS Number:5786-21-0

PubChem identifier:2818

SMILES:CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

InChi:InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3

InChiKey:ZUXABONWMNSFBN-UHFFFAOYSA-N

MDL number:MFCD00153785

Appearance:Yellow solid

References for Clozapine

References are publications that support the biological activity of the product

DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands.

Goutaudier et al (2019) eNeuro 6 : (5) Read more (PubMedID: 31562177)

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine.

Gomez et al (2017) Science 357(6350) : 503-507 Read more (PubMedID: 28774929)

Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects.

Strange PG (2001) Pharmacol Rev 53(1) : 119-33. Read more (PubMedID: 11171942)

Differential regulation of rat 5-HT2A and 5-HT2C receptors after chronic treatment with clozapine, chlorpromazine and three putative atypical antipsychotic drugs.

Kuoppamã?ki M et al (1995) Neuropsychopharmacology 13(2) : 139-50. Read more (PubMedID: 8597525)

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.

Sunahara RK et al (1991) Nature 350(6319) : 614-9. Read more (PubMedID: 1826762)

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