Chitosan 

Chitosans are a large group of substances with diverse properties due to their varying degrees of deacetylation and molecular weights. On the following pages, we would like to introduce you to our product portfolio in more detail and demonstrate the possibilities offered by chitosan.

Quality lines

HMC has introduced different quality lines to meet the demands of each industry. The following lines are offered:

Chitoscience ® - for scientific needs in universities

Chitoceuticals ® - for medical technology and the pharmaceutical industry, this quality line is further divided into 3 different levels - depending on the stage of their development:

Chitoceuticals ® Standard - Applications in medical technology and initial pharmaceutical research

Chitoceutical ® GMP compliant - Medical devices, use of chitosan in pharma as an excipient

Chitoceuticals ® GMP - Application of chitosan as an API, usually a derivatization of the chitosan is carried out first - read more about this in the contract manufacturing section

Origin of Chitosan

Generally, chitosan is obtained by deacetylation of chitin. The chitin for HMC's chitosan is mainly derived from Crustacea ( Chionoecetes opilio ) .InquiryOther sources (e.g. shrimp, squid, mushrooms or insects) are also possible.

How do you find the right chitosan?

HMC's chitosans are classified according to different specifications. This allows you to select the right product and ensure consistent properties. The first number after the quality line indicates the degree of deacetylation of the chitosan. The degree of deacetylation describes the amount of free amino groups on the molecule.

Degree of deacetylation % = 1-F A = ​​100 - degree of acetylation

The higher the number, the more “active” the molecule can be.

The second number in our product names represents the viscosity of the chitosans. Dynamic viscosity is measured as a 1% solution in 1% acetic acid or, for derivatives, in water. Before measurement, the chitosan is dissolved for at least 2 hours with stirring. Viscosity also provides an indication of molecular weight, which, however, cannot be directly related to molecular weight.

Example of the product classification "Chitoceuticals standard Chitosan 95/1500":

Chitoceuticals standard line,

95% Deacetylated (FA = 0.1), 5% Acetylated

1500mPas viscosity

Properties of chitosan

The properties of chitosan can vary depending on the chitosan used. Chitosans are characterized by the following properties, among others :

Molecular formula: (C 8 H 11 NO 4 ) n

CAS No.: 9012-76-4

Molecular weight per unit: 161.15 g/mol

High charge carrier density

Biodegradable

Non-toxic, LD 50 16 g/kg body weight

Antibacterial, antifungal

Film and fiber forming, cross-linking

Immobilization of living organisms

Anti-inflammatory

Wound healing

Stimulation of the immune system and metabolism

Odor-binding

Binding ability to proteins, heavy metals, suspended particles

Not thermoplastic, decomposes at 280°C

Examples of chitosan applications

Drug delivery systems in various forms such as microgranules, microspheres, hydrogels, nanoparticles or nanofibers for e.g. oral, transdermal, nasal or vaginal applications

non-viral vectors for the transport of nucleic acids such as RNA (e.g. for mRNA vaccines) or DNA

Active ingredient boosters for vaccines

Scaffold in the field of tissue engineering for the regeneration of e.g. heart muscle tissue, bones, skin, eyes or nerves

Wound dressings with hemostatic and antibacterial effects

Learn more in our Publications section . Here we present current publications on chitosan and its applications.

Chitosan oligomer

Chitosan oligomer is a chitosan oligosaccharide consisting of D-glucosamine linked to β-(1➔ 4) units. It can be produced by deacetylation and hydrolysis of chitin.

Applications Chitosan Oligomer

Tissue Engineering: Chitosan oligomers support the differentiation of mesenchymal stem cells into osteoblasts – formation of bone tissue

Drug transport and release: Formation of complexes e.g. with plasmid DNA, targeted release of drugs e.g. in the lungs or intestines

Wound treatment: Acceleration of wound healing processes, combination of chitosan and chitosan oligomers for wound dressings

Use of antibacterial effects

Effect against fungal infestation of plants

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