IAV H5N2 (A/American green-winged teal/California/HKWF609/2007) Hemagglutinin [His] 

Catalog # DAG2228

Recombinant IAV H5N2 (A/American green-winged teal/California/HKWF609/2007) Hemagglutinin (a.a. 19-506) from HEK293 cells [His]

Product Overview:C-terminal 6xHis tagged HA(H5N2) (A/American green-winged teal/California/HKWF609/2007(H5N2)) protein (a.a.19-506)

Nature:Recombinant

Tag/Conjugate:His

Purity:≥ 95%

Format:Each vial contains 100 μg purified protein in PBS.

Concentration:1 mg/ml

Preservative:None

Storage:2-8°C short term, -20°C long term

Introduction:Influenza A virus causes influenza in birds and some mammals, and is the only species of influenza virus A. Influenza virus A is a genus of the Orthomyxoviridae family of viruses. Strains of all subtypes of influenza A virus have been isolated from wild birds, although disease is uncommon. Some isolates of influenza A virus cause severe disease both in domestic poultry and, rarely, in humans. Occasionally, viruses are transmitted from wild aquatic birds to domestic poultry, and this may cause an outbreak or give rise to human influenza pandemics.

Antigen DescriptionInfluenza (flu) is a respiratory infection in mammals and birds. This virus is divided into three main types (A, B and C). Influenza A is found in a wide variety of bird and mammal species and is further divided into subtypes based on differences in the membrane proteins hemagglutinin (HA) and neuraminidase (NA). H5N2 is a subtype of the species Influenzavirus A. Low pathogenic avian inluenza H5N2 virus in poultry gained accentuated virulence in the United States and Mexico. A highly pathogenic strain of H5N2 caused flu outbreaks with significant spread to numerous farms, resulting in great economic losses in 1983 in Pennsylvania, USA in chickens and turkeys, in 1994 in Mexico in chickens and a minor outbreak in 1997 in Italy in chickens. In 2006, an H5N2 outbreak on a single farm in South Africa resulted in the destruction of all its sixty ostriches. The strain was similar to the one that caused outbreaks in South Africa 2004/2005. In 2007, a low-pathogenic strain of H5N2 was found in samples collected from 25, 000 turkeys in Pendleton County, West Virginia in a routine testing prior to their slaughter. In late 2007 (December 21), an H5N2 outbreak was found in the Dominican Republic, in a Suburb of Higuey City, on the eastern side of the island. In May and June 2008, there were three outbreaks of low-pathogenic H5N2 avian flu in birds at three locations in the central, northern, and southern parts of Haiti. "The outbreaks began on May 20 and appeared to be ongoing", as of June 17, 2008. In China, inactivated H5N2 has been used as a vaccine for H5N1. Hemagglutinin (HA) is a single-pass type I integral membrane glycoprotein from the influenza virus, and comprises over 80% of the envelope proteins present in the virus particle. The HA is a trimer with a receptor binding pocket on the globular head of each monomer. In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. Binding of HA to sialic acid-containing receptors on the surface of its target cell brings about the attachment of the virus particle to the cell and forms a endosome. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the hydrophobic portion "fusion peptide". After which, virus penetrates the cell and pours its contents including the RNA genome into the cytoplasm mediated by fusion of the endocytosed virus particle's own membrane and the endosomal membrane. Hemagglutinin plays a major role in the determination of host range restriction and virulence

KeywordsInfluenzavirus A; Influenza A virus; Influenza A virus H5N2 HA; H5N2 HA; IAV H5N2 HA

견적 문의: aibiohub@aibiohub.co.kr
 홈페이지: www.aibiohub.co.kr