Glucose PEG Succinimidyl Carboxymethyl Ester 

SKU: GLUC-SCM

Categories: Activated PEGs for Amine PEGylation, PEGs WITH GLUCOSE, PEGs WITH NHS ESTER

Description

Glucose PEG Succinimidyl Carboxymethyl Ester with superior quality specification of ≥90% Substitution.

JenKem Technology’s Glucose PEG Succinimidyl Carboxymethyl Ester is a high quality amine reactive PEG product with a succinimidyl carboxymethyl ester active group and a targeting glucose group. Glucose PEG Succinimidyl Carboxymethyl Ester reacts with amine group of lysine(s) at room temperature in less than 1hr, at pH 7-8. The presence of the monosaccharide sugar group (Glucose) increases significantly the selectivity of the PEGylation reaction.

JenKem Technology offers Glucose PEG Succinimidyl Carboxymethyl Ester with MW 35000 (GLUC-SCM-35K), in 1g and 10g packing sizes. Different MW of Glucose PEG Succinimidyl Carboxymethyl Ester products may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

References:

Wei, G, et al., Glucose Transporter 1 (GLUT1)-Targeting and Hypoxia-Activated Mitochondria-Specific Chemo-thermal Therapy via a Glycosylated Poly (amido amine)/Celastrol (PAMAM/Cel) Complex. Journal of Colloid and Interface Science. 2021.

He, H., et al., Development of mannose functionalized dendrimeric nanoparticles for targeted delivery to macrophages: use of this platform to modulate atherosclerosis, Translational Research, 2018, Vol. 193, P. 13-30.

Drappier, C., pH-Responsive Surface Shielding By Electrostatic Adsorption of PEG Segments With Anionic Chain End, Universite Bordeaux, 2013.

Weaver, E.A., et al., Effects of Shielding Adenoviral Vectors with Polyethylene Glycol on Vector-Specific and Vaccine-Mediated Immune Responses, Human Gene Therapy 2008, 19:1369–1382.

Note: Starting July 2016, Glucose PEG Succinimidyl Carboxymethyl Ester is the new name of the product Glucose PEG NHS (MW 35000 (GLUC-NHS-35K)

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization directly from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

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